Scabies is a contagious skin disease in humans caused by a tiny microscopic mite that lives under the skin. Intense itchiness, main symptom of the disease leads to extreme scratching causing mechanical damage of the skin. This facilitates secondary bacterial infections associated with potentially life threatening sequalae. Scabies is highly prevalent in overcrowded and disadvantaged communities. It is considered a neglected disease due to no available vaccine, no rapid diagnostic tests and few treatment options available. Limited egg killing activity/suboptimal efficacies of the existing drugs, patient incompliance to repeat treatments and emerging resistance are major concerns. Therefore, our objective is to develop a single-dose treatment targeting the entire parasitic lifecycle. Abametapir is an excellent head louse and louse egg killer compound. It showed exceptional scabies mite and egg killing abilities in laboratory studies. This project may have future translational implications for patients suffering from this underrated, neglected disease.